Local application of EMLA and glyceryl trinitrate ointment before venepuncture

Glyceryl trinitrate ointment in angina pectoris.

Skin absorption of glyceryl trinitrate (GTN) has been recognized for a long time. The effect of GTN and a placebo ointment in prevention of chest pain has been assessed and compared by studying the exercise capacity in 17 patients with angina pectoris. The placebo cream was ineffective but the GTN ointment was found to have beneficial effect in relief of pain in 16 cases. This was established b...

Glyceryl trinitrate before coronary angiography.

Case against routine use of glyceryl trinitrate before coronary angiography.

to the degree of coronary narrowing, 47 consecutive chest pain patients were studied without premedication by analysing selective coronary angiograms before and after glyceryl trinitrate. Proximal coronary diameters were measured in superimposed frames with callipers. Lumen diameter increased after glyceryl trinitrate 15 ± 2 per cent in the left main, 18 ± 2 per cent in the left anterior descen...

Glyceryl trinitrate (nitroglycerin) ointment and isosorbide dinitrate: a review of their pharmacological properties and therapeutic use.

Sublingual glyceryl trinitrate (nitroglycerin) is the most widely used drug in the treatment of angina pectoris, but its use is limited due to its short acting effect. Recent investigations have shown that some longer acting nitrates administered orally or topically have a long acting antianginal effect. The mechanism of the antianginal effect of nitrates is multifactorial. Nitrates increase ox...

Comparison with glyceryl trinitrate

The coronary haemodynamic effects of nifedipine and glyceryl trinitrate were compared in 22 patients undergoing investigations for suspected coronary artery disease. Myocardial blood flow was estimated by the coronary sinus thermodilution technique. In sinus rhythm nifedipine increased mean coronary sinus flow from 135 ml/min to 152 m/min, and reduced arterio-coronary sinus oxygen difference fr...